Effect of tramadol on liver enzymes, oxidative stressm and some antioxidant markers in male rabbits

An overdose of tramadol is a frequent reason for hepatic and renal toxicity possible death.Hence, this study aimed at investigating the impact on serum liver enzyme, oxidative stressm som antioxidant markers in male rabitts. Methods: A total 20 growing rabbits (7.5 weeks old) reared under high ambient temperature were divided into two equal groups, 10 each. The first group control administered with normal saline second tramadol-treated rats (50 mg/kg b.w. orally) 30. Blood samples withdrawn to measure aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP), Glutathione (GSH), malondialdehyde (MDA) levels catalase (CAT), activities assayed. Results: In group, significant increases aminotransferases, alanin aminotransferases activities, decreases glutathione determined compared group. Conclusion: administration produces noticeable biochemical changes dosedependent manner associated increased enzyme stress decreased antioxidative activity.